我主要專注于利用穩定同位素地球化學來探究地球系統的多個不同的方面——尤其渴望對于在地質學、生物學及全球/區域氣候變化相互關聯及作用的領域展開探索。我主要的研究經曆在于創建、發展新興的高精度穩定同位素測試方法(如：三氧同位素、團簇同位素)并将其應用于不同的地球體系中，以同位素的分餾或團簇現象的形成和消褪來制約地球物質轉化過程中的化學熱動力學平衡或擾動狀态，從而見微知著，诠釋全球的物質循環及環境變化。具體研究方向包括：（1）C-H-O-S同位素體系研究俯沖帶流體活動及相關元素分異和深部物質循環。（2）15N15N團簇同位素示蹤行星大氣圈的演化。（3）三氧同位素對于全球水汽循環及局域古濕度古水文的制約。（4）碳酸鹽13C18O團簇同位素用于古氣候中的測溫。（5）13C-D, D-D雙團簇同位素體系示蹤甲烷成因。

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o Yeung L. Y., Li S. (李姝甯), Kohl I. E., Haslun J. A., Ostrom N. E., Hu H., Fischer T. P., Schauble E. A. and Young E. D. (2017) Extreme enrichment in atmospheric 15N15N. Science Advances. 3, eaao6741.

o Li S. (李姝甯), Levin N. E., Soderberg K., Dennis K. J. and Caylor K. K. The triple oxygen isotope composition of leaf waters in Mpala, central Kenya. (2017) Earth Planet Sci. Lett. 468, 38-50.

o Young E. D., Kohl I. E., Lollar B. S., Etiope G., Rumble D., Li S. (李姝甯), Haghnegahdar M. A., Schauble E. A., McCain K. A., Foustoukos D. I., Sutclife C., Warr O., Ballentine C. J., Onstott T. C., Hosgomez H., Neubeck A., Marques J. M., Pérez-Rodriguez I., Rowe A. R., LaRowe D. E., Magnabosco C., Yeung L. Y., Ash J. L. and Bryndzia L. T. (2017) The relative abundances of resolved 12CH2D2 and 13CH3D and mechanisms controlling isotopic bond ordering in abiotic and biotic methane gases. Geochim. Cosmochim. Acta 203, 235-264.

o Li S. (李姝甯), Levin N.E. and Chesson L.A. (2015) Continental scale variation in 17O-excess of meteoric waters in the United States. Geochim. Cosmochim. Acta 164, 110-126.

o Passey B. H., Hu H., Ji H. Montanari S., Li S., Henkes G. A. and Levin N. E. (2014) Triple oxygen isotopes in biogenic and sedimentary carbonates. Geochim. Cosmochim. Acta 141, 1-25.

o Freeman H., Feng X., Li S., Zegre N., Lin J. C., Bowen G. (2014) High frequency trends in the isotopic composition of Superstorm Sandy. In Learning from the Impacts of Superstorm Sandy. Bennington J. B. and Farmer E. C., Elsevier.

o Sheng Y., Zheng Y, Li S. and Hu Z. (2013) Element mobility during continental collision: insights from polymineralic metamorphic vein with UHP eclogite in the Dabie orogen. Jounal of Metamorphic Geology. 31, 221-241.

o Berman S. F., Levin N. E., Landais A., Li S. and Owano T. (2013) Measurement of δ18O, δ17O and 17O-excess in water by off-axis integrated cavity output spectroscopy and isotope ratios mass spectrometery. Anal. Chem. 85, 10392-10398.

o Gao X., Li S. and Zheng Y. (2011) On the study multiphase solid inclusions in UHP metamorphic minerals. Acta Petrologica Sinica. 27, 469-489. (in Chinese, with English abstract)

o Li S., Yeung L. Y., Young E. D., Ostrom N. E. and Haslun J. A. (2015) Triple-isotopologue analysis of N2 as a tracer of the global nitrogen cycle. (5th International Workshop on Clumped Isotopes, St Petersburg, FL, USA).

o Li S, Levin N. E, Chesson L. A. (2011) Triple oxygen isotope composition of tap waters from the conterminous United States. (Isoscapes Meeting, West Lafayette, IN, USA).

o David Elliott Memorial (2013, JHU研究生獎學金)

o Ehleringer Prize (2011, Isoscapes會議 ‘best talk’)

o Ernst Cloos Memorial (2010, JHU研究生獎學金)

國際SCI期刊審稿人：《Geochim. Cosmochim. Acta》《Water》《Journal of Geophysical Research》《Earth Planet Sci. Lett.》